Evaluation of AI-assisted LDCT Screening in Lung Cancer

This multicenter pragmatic randomized controlled trial evaluates whether AI-assisted interpretation of low-dose CT (LDCT) improves lung cancer screening performance compared with standard reading. Eligible participants are randomized to AI-assisted or conventional interpretation. The study assesses diagnostic accuracy, efficiency, lung cancer incidence, mortality, recurrence, and smoking cessation outcomes. Results will inform the clinical utility and potential implementation of AI-assisted LDCT in routine screening practice.

NCT Number	NCT07280559
Lead Sponsor	Taipei Veterans General Hospital, Taiwan Collaborators: Far Eastern Memorial Hospital, Taipei Municipal Guandu Hospital, Da Chien General Hospital, Kinmen Hospital, Ministry of Health and Welfare, Ministry of Health and Welfare, Taiwan
Conditions	Lung Cancer
Enrollment	1,120 participants
Start Date	2025-12-11
Primary Completion	2027-12-31 (estimated)
Study Completion	2031-12-31 (estimated)
Updated on ClinicalTrials.gov	2025-12-12