Clinical Trial

Comparing Microneedling and Injectable Platelet Rich Fibrin to Hyaluronic Acid In Papilla Reconstruction

Study acronym: (PRF) (HA)
Active, Not Recruiting Early Phase 1
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Record status
This record was last updated December 12, 2025 (before its estimated March 2026 completion). Its status may not reflect the trial's current state.
Summary
This randomized split-mouth clinical trial aims to compare the clinical effectiveness of microneedling combined with injectable platelet-rich fibrin (i-PRF) versus hyaluronic acid (HA) gel injection in the reconstruction of Class I interdental papilla loss. The study hypothesizes that MN + i-PRF will yield greater papillary regeneration, offering a minimally invasive, biologically active alternative to traditional surgical approaches for soft-tissue esthetic rehabilitation.
Trial Details
NCT Number NCT07280507
Lead Sponsor King Abdulaziz University
Conditions Papilla Reconstruction
Enrollment 7 participants
Start Date 2025-11-24
Primary Completion 2026-03 (estimated)
Study Completion 2026-09-30 (estimated)
Updated on ClinicalTrials.gov 2025-12-12