Thrombolysis in Early Acute Ischemic Stroke Trial-Blood Pressure Management

This study is a Phase II, exploratory, prospective, multicenter, open-label, randomized controlled clinical trial with blinded endpoint assessment setting on the safety of an adjusted versus a conventional blood pressure management strategy during intravenous thrombolysis in AIS patients, with a key focus on the incidence of symptomatic intracranial hemorrhage (sICH).

NCT Number	NCT07279259
Lead Sponsor	Shanghai East Hospital Collaborators: Shanghai 7th People's Hospital
Conditions	Stroke, Acute Ischemic Stroke, Thrombolysis
Enrollment	340 participants
Start Date	2026-01-15
Primary Completion	2027-12-01 (estimated)
Study Completion	2028-08-05 (estimated)
Updated on ClinicalTrials.gov	2026-01-21