PACE-AF: Prospective Analysis of Cardiac Electrostimulation and Atrial Fibrillation

PACE-AF is a prospective, observational patient registry designed to evaluate the impact of pacemaker algorithms on atrial fibrillation (AF) incidence, progression, and clinical outcomes in patients implanted with dual-chamber pacemakers. The registry aims to include 400-500 patients with longitudinal follow-up. Primary outcomes are progression to permanent AF and all-cause mortality. Secondary outcomes include quality of life, hospitalization, and cardiovascular events.

NCT Number	NCT07279207
Lead Sponsor	Ilya Lukin
Conditions	Atrial Fibrillation, Sick Sinus Syndrome, Atrioventricular Block
Enrollment	500 participants
Start Date	2025-12
Primary Completion	2027-12 (estimated)
Study Completion	2028-12 (estimated)
Updated on ClinicalTrials.gov	2025-12-12