Hemodiafiltration Versus Hemodialysis in Older People

This study will compare the impact of two hemodialysis techniques on fatigue and post-dialysis recovery time in patients aged 85 years and older. These two techniques are high-flux hemodialysis (HD) and hemodiafiltration (HDF). Patients will receive the treatment over two periods: if period 1 is HD then period 2 will be HDF. Every patient will be his/her own control, this is why it is called cross-over. Each period will last three months. Between the two periods, patients will receive a traditional low-flux hemodialysis. These two techniques are widely used worldwide and their side-effects are well-known and do not put the patients at risk. HDF has been shown to improve survival in patients with a mean age of 58 years. But a previous study from the investigators' group showed that HDF causes a prolonged recovery time in older patients. This randomized trial aims to elucidate this question.

NCT Number	NCT07278973
Lead Sponsor	AUB Santé
Conditions	Hemodialysis, Hemodiafiltration, Fatigue Symptom, Quality of Life of Patients, Older People
Enrollment	62 participants
Start Date	2026-02-19
Primary Completion	2026-12-19 (estimated)
Study Completion	2026-12-19 (estimated)
Updated on ClinicalTrials.gov	2026-02-23