The RheumSafer Study: Improving Medication Appropriateness in People With Rheumatic Conditions

The goal of this prospective observational quality improvement study is to determine if a physician tool, MedSafer, combined with educational brochures for patients, can help to reduce the use of 'potentially inappropriate medications' (PIMs) in adults aged 60 and over with rheumatic conditions and polypharmacy (taking 5 or more regular medications). Researchers will follow participants during usual rheumatic disease care. They will compare the rate of PIM deprescribing (stopping medications or reducing the dose) before and after the introduction of the following interventions: * MedSafer reports provided to treating physicians * EMPOWER consumer brochures provided to participants Participants will complete 4 study visits over 18-20 months during which researchers will collect information on medication changes, serious adverse events (emergency visits or hospitalizations), and quality of life.

NCT Number	NCT07278609
Lead Sponsor	McGill University Health Centre/Research Institute of the McGill University Health Centre Collaborators: The Arthritis Society, Canada
Conditions	Rheumatic Diseases, Inflammatory Arthritis, Systemic Lupus Erthematosus (SLE), Vasculitis, Muskuloskeletal Diseases, Systemic Autoimmune Diseases
Enrollment	100 participants
Start Date	2025-10-29
Primary Completion	2028-03-31 (estimated)
Study Completion	2028-06-30 (estimated)
Updated on ClinicalTrials.gov	2026-05-01