TB SCReening Improves Preventive Therapy Uptake in Pregnant Women With HIV

Because pregnant women have been excluded from clinical research, including tuberculosis (TB) research, little is known about diagnosing, treating and preventing TB in pregnant women. We plan to perform a two-stage randomized trial that will identify best practices for screening pregnant and postpartum women for active TB (screening by symptoms vs. C-reactive protein levels) and the optimal timing of TPT initiation, relative to pregnancy (immediately during pregnancy or deferred to postpartum). Because undiagnosed TB among pregnant women with HIV is associated with many devastating complications to both the mother and fetus, this research has the potential to improve maternal and birth outcomes worldwide.

NCT Number	NCT07278453
Lead Sponsor	University of California, San Francisco Collaborators: Makerere University, National Heart, Lung, and Blood Institute (NHLBI)
Conditions	Pregnant HIV Positive Women, HIV, Tuberculosis (TB)
Enrollment	1,500 participants
Start Date	2026-06
Primary Completion	2031-06 (estimated)
Study Completion	2031-06 (estimated)
Updated on ClinicalTrials.gov	2025-12-12