An Exercise Intervention for Improving Mental and Physical Health in Patients With Primary Brain Tumors and Their Caregivers, ET-NEURO Trial

This clinical trial evaluates the effects of a partnered exercise program, called Exercise Together, on participants with primary brain tumors and their caregivers. Standard treatments for primary brain tumors require extensive caregiver support, and both patients and caregivers experience high psychological distress and physical burden as a result. While exercise is known to improve outcomes in cancer patients, its impact on primary brain tumor patients and caregivers remains unstudied. Exercise Together is a supervised, group exercise program previously studied in patients with other types of cancer, though never in patients with primary brain tumors or their caregivers. Exercise Together uses functional resistance training to target muscle groups essential for everyday activities to improve daily functioning. Since exercises are done in a partnered format, Exercise Together is also designed to foster teamwork and strengthen the relationship between the patient and their caregiver. This program may be safe, feasible, and effective in improving the mental and physical health of primary brain tumor patients and their caregivers.

NCT Number	NCT07278440
Lead Sponsor	OHSU Knight Cancer Institute Collaborators: National Cancer Institute (NCI), Oregon Health & Science University (OHSU)
Conditions	Primary Brain Neoplasm
Enrollment	36 participants
Start Date	2026-07-10
Primary Completion	2027-05-02 (estimated)
Study Completion	2027-08-02 (estimated)
Updated on ClinicalTrials.gov	2026-07-16