Effects of Active Upper-Limb Exoskeleton Training in Simulated Hyper-Gravity on Fine Motor Performance, Brain-Muscle Connectivity, Cardiovascular System and Stress Responses in Real Hyper-Gravity

The aim of the study presented here is to assess the effects of exoskeleton training on performance in a real hypergravity situation. In particular, it will analyze fine motor control, autonomic nervous system regulation and metabolic responses. To this end, the study will compare two groups during a pointing exercise in a centrifuge (hypergravity). One group will have been trained to do this exercise using an exoskeleton, while the other will have been familiarized with the task without the exoskeleton. It will assess whether the exoskeleton can be an effective and accessible training tool for astronauts.

NCT Number	NCT07278245
Lead Sponsor	Centre National d'Etudes Spatiales Collaborators: MEDES Institut de Médecine et de Physiologie Spatiales, Toulouse
Conditions	Motor Learning and Physiological Adaptation
Enrollment	12 participants
Start Date	2025-10-27
Primary Completion	2025-11-27 (estimated)
Study Completion	2026-01-27 (estimated)
Updated on ClinicalTrials.gov	2026-02-05