Central Haemodynamics and Pacing for AV Block

A randomized, single-blind study comparing two pacing strategies in patients with atrioventricular block requiring permanent pacemaker implantation. This trial evaluates the impact of conduction system pacing (left bundle branch area pacing) versus standard right ventricular pacing on central hemodynamics, cardiac function, and patient quality of life over 12 months. The study will enroll 124 patients from two Estonian tertiary hospitals and measure central systolic arterial pressure as the primary outcome, with secondary assessments of arterial stiffness, echocardiographic parameters, electrical activation patterns, and quality of life scores.

NCT Number	NCT07276490
Lead Sponsor	University of Tartu Collaborators: North Estonia Medical Centre, Tartu University Hospital
Conditions	Atrioventricular Block, Pacing Therapy, Right Ventricular Pacing, Conduction System Pacing
Enrollment	124 participants
Start Date	2025-11-28
Primary Completion	2027-06-01 (estimated)
Study Completion	2027-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-03-09