Polidocanol Foam With or Without Transdermal Laser in Varicose Veins

This randomized, parallel clinical trial with blinded outcome assessment will compare the clinical and aesthetic outcomes of polidocanol foam sclerotherapy alone versus polidocanol foam associated with long-pulse 1064 nm Nd:YAG transdermal laser in the treatment of lower-limb tributary varicose veins. The primary endpoint is venous occlusion rate at 30 days, assessed by Doppler ultrasound. Secondary outcomes include cutaneous hyperpigmentation, pain, patient satisfaction, and adverse events.

NCT Number	NCT07276243
Lead Sponsor	Hospital Universitario Pedro Ernesto
Conditions	Varicose Veins
Enrollment	102 participants
Start Date	2026-03-24
Primary Completion	2027-08-30 (estimated)
Study Completion	2027-12-30 (estimated)
Updated on ClinicalTrials.gov	2026-05-05