Brain-Stomach Circuits in Chronic Nausea

The goal of this study is to determine whether stimulation of the brain-stomach connection can influence stomach activity in healthy adults and in individuals suffering from chronic nausea. The main questions it aims to answer are: * What are the best brain sites to influence the stomach? * What are the effects of different stimulation patterns on stomach activity? * Does the stimulation affect the sensation of nausea in participants suffering from chronic nausea? Researchers will use a non-invasive method of brain stimulation called Transcranial Magnetic Stimulation (TMS) and will record stomach responses with skin electrodes on the abdomen. Participants will: * Visit the clinic at least once, and for up to 9 times more over the course of several months. * Receive TMS while sitting in a chair similar to a dentist's chair. * Drink water or consume a test meal during each study visit.

NCT Number	NCT07276035
Lead Sponsor	David Levinthal Collaborators: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions	Chronic Nausea and Vomiting Syndrome
Enrollment	219 participants
Start Date	2026-01-28
Primary Completion	2030-07 (estimated)
Study Completion	2031-07 (estimated)
Updated on ClinicalTrials.gov	2026-07-24