Clinical Trial

Frequency-Dependent Effects of Auricular Vagus Nerve Stimulation on Autonomic and Cardiovascular Parameters

Study acronym: AVNS-DRC
Not Yet Recruiting
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Record status
This record was last updated December 10, 2025 (before its estimated January 31, 2026 completion). Its status may not reflect the trial's current state.
Summary
This randomized, sham-controlled, crossover study investigates the acute autonomic effects of transcutaneous cervical vagus nerve stimulation (tcVNS) applied at five different frequencies (0 Hz/sham, 10 Hz, 25 Hz, 50 Hz, 100 Hz) in healthy adults. The primary objective is to determine how stimulation frequency modulates heart rate variability (HRV), blood pressure, and respiratory rate. The study aims to establish a frequency-specific dose-response model using validated physiological measurements.
Trial Details
NCT Number NCT07274332
Lead Sponsor SEFA HAKTAN HATIK
Conditions Vagus Nerve Stimulation, Autonomic Nervous System, Heart Rate, Blood Pressure, Respiration, Healthy Volunteers
Enrollment 36 participants
Start Date 2025-12-22
Primary Completion 2026-01-31 (estimated)
Study Completion 2026-03-15 (estimated)
Updated on ClinicalTrials.gov 2025-12-10