Periodontal Health and Sodium Bicarbonate Toothpaste

The goal of this clinical trial is to determine whether sodium bicarbonate fluoride toothpaste can help maintain periodontal health in adults who have undergone non-surgical periodontal treatment. The main question it aims to answer is: Does daily use of toothpaste affect the following outcomes: clinical oral health (plaque scores, gingival bleeding scores and periodontal pocket depths), salivary biochemical markers and the oral microbiome. Outcomes measures will be recorded at 0,3, and 6 months, during which time participants will receive either the treatment or placebo toothpaste and undergo oral hygiene instruction and PMPR over 6 months.

NCT Number	NCT07274189
Lead Sponsor	University of Plymouth Collaborators: HALEON
Conditions	Periodontal Diseases
Enrollment	100 participants
Start Date	2024-12-04
Primary Completion	2026-10-20 (estimated)
Study Completion	2027-01-30 (estimated)
Updated on ClinicalTrials.gov	2025-12-22