Clinical Trial

Effects of Positive End-Expiratory Pressure (PEEP) and Prone Positioning in Healthy Volunteers on Venous Hemodynamics Including the Venous Excess Ultrasound (VExUS) Score

Study acronym: VeNIVPro
Recruiting
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Record status
This record was last updated December 9, 2025 (before its estimated June 2026 completion). Its status may not reflect the trial's current state.
Summary
The hemodynamic effects of proning and PEEP may vary depending on pre- existing cardiac function, lung mechanics, and volume status, and the available evidence remains conflicting. The impact on the VExUS score of these manoeuvres is unclear. This study aims to assess the effects of PEEP in supine and prone position on the VExUS score as well as echocardiographic parameters in a cohort of healthy volunteers.
Trial Details
NCT Number NCT07273617
Lead Sponsor University Hospital, Basel, Switzerland
Conditions Venous Hemodynamics
Enrollment 40 participants
Start Date 2025-09-25
Primary Completion 2026-06 (estimated)
Study Completion 2026-06 (estimated)
Updated on ClinicalTrials.gov 2025-12-09