Clinical Trial

A Study to Evaluate the Effect of a Test (Sodium Bicarbonate) Toothpaste on the Oral Microbiome

Completed
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Summary
The aim of this 12-week clinical study is to evaluate the effect of a toothpaste containing sodium bicarbonate over time on the oral microbiome and to explore its effect in comparison to a regular fluoride toothpaste in participants with localized gingivitis.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2025-11-27.
Status change: Recruiting → Completed 2026-03-09
Trial Details
NCT Number NCT07273539
Lead Sponsor HALEON
Conditions Gingivitis
Enrollment 74 participants
Start Date 2025-10-27
Primary Completion 2026-02-27 (estimated)
Study Completion 2026-02-27 (estimated)
Updated on ClinicalTrials.gov 2026-03-11