Clinical Trial

Study of QLC5513 in Combination With Epalolimab Tovolimab (QL1706) ± Platinum in Patients With Advanced or Metastatic Malignant Solid Tumors

Not Yet Recruiting Phase 1/2
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Summary
The goal of this Phase Ib/II interventional study is to evaluate the safety, tolerability, pharmacokinetics and efficacy of QLC5513 combined with QL1706± platinum in the treatment of patients with advanced or metastatic malignant solid tumors. This study is divided into two phases: Phase Ib is the combined dose escalation phase, where dose escalation of QLC5513 combined with QL1706± platinum is conducted and RP2D is explored; In the Phase II tumor type expansion study stage, the primary objective is to evaluate the objective response rate (ORR) of QLC5513 combined with QL1706± platinum-based treatment in patients with advanced or metastatic malignant solid tumors.
Trial Details
NCT Number NCT07272590
Lead Sponsor Qilu Pharmaceutical Co., Ltd.
Conditions Metastatic Solid Tumors
Enrollment 290 participants
Start Date 2025-12-30
Primary Completion 2027-06 (estimated)
Study Completion 2031-08 (estimated)
Updated on ClinicalTrials.gov 2025-12-09