Right Ventricular Function Changes After CIED Implantation: The RIGHT-CIED Study

This study aims to understand how the right side of the heart changes in people who receive an implantable cardiac electronic device (CIED), such as a pacemaker, ICD, or CRT device. The right ventricle (RV) can sometimes be affected after these devices are placed, but the reasons and timing are not well understood. To investigate this, we will examine participants at two time-points: before their device is implanted and again six months later. At each visit, we will assess heart function using echocardiography, a non-contrast cardiac MRI scan, and an ultrasound score of venous congestion called the VEXUS score. We will also take a small blood sample to measure a biomarker called FGF-23, which may reflect changes in heart function. The study does not involve any experimental treatment, and all implanted devices are part of routine medical care. The imaging tests and blood samples are for research purposes only. By comparing the measurements before and after device implantation, we hope to better understand how CIEDs influence right-sided heart function and whether imaging findings are related to changes in blood biomarkers.

NCT Number	NCT07272395
Lead Sponsor	Istanbul University - Cerrahpasa
Conditions	Right Ventricular Dysfunction
Enrollment	40 participants
Start Date	2025-08-15
Primary Completion	2026-10-21 (estimated)
Study Completion	2026-11-25 (estimated)
Updated on ClinicalTrials.gov	2025-12-16