Research on Anesthesia Depth Control Strategy Based on Continuous and Non-invasive Monitoring of Exhaled Breath

This study aims to propose a strategy for controlling the depth of anesthesia based on continuous and non-invasive monitoring of exhaled breath: BIS value during intravenous-inhalation combined anesthesia is predicted according to the real-time exhaled concentrations of sevoflurane and propofol, so as to achieve the depth of anesthesia management for patients who cannot use standard BIS. Furthermore, the relationship between anesthetic concentration and depth of anesthesia was analyzed in different subgroups.

NCT Number	NCT07272044
Lead Sponsor	Second Affiliated Hospital, School of Medicine, Zhejiang University
Conditions	Anesthesia
Enrollment	500 participants
Start Date	2024-03-16
Primary Completion	2027-03-15 (estimated)
Study Completion	2029-03-15 (estimated)
Updated on ClinicalTrials.gov	2025-12-09