Clinical Trial

PONDER: Pelvic Peritonectomy in Early Stage Ovarian Tumors

Study acronym: PONDER
Not Yet Recruiting
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Summary
Early-stage ovarian tumors represent approximately 30% of all newly diagnosed ovarian cancers. Current international guidelines recommend random peritoneal biopsies for surgical staging, but the diagnostic yield of these biopsies remains limited. The PONDER study aims to evaluate whether standardized surgical procedure and pathology assessment of wider peritoneal pelvic biopsies can increase the detection rate of microscopic peritoneal implants and micrometastases in patients with early-stage ovarian tumors. This multicenter, prospective, single-arm study includes both minimally invasive and open surgical approaches, with a standardized gross and microscopic evaluation of the resected peritoneal specimens
Trial Details
NCT Number NCT07271914
Lead Sponsor Ospedale Santa Croce-Carle Cuneo
Conditions Early Stage Ovarian Tumors, Peritoneal Carcinosis
Enrollment 390 participants
Start Date 2026-02
Primary Completion 2030-02 (estimated)
Study Completion 2032-08 (estimated)
Updated on ClinicalTrials.gov 2025-12-09