Oxidative Stress Effects of TIVA, CIVA, and Balanced Anesthesia in VATS

The primary objective of our study is to compare the effects of total intravenous anesthesia (TIVA), combined intravenous-volatile anesthesia (CIVA), and balanced anesthesia (BAL) methods on perioperative oxidative stress parameters, such as Malondialdehyde (MDA), Total Oxidant Status (TOS), Total Antioxidant Status (TAS), and Superoxide Dismutase (SOD), in patients undergoing video-assisted thoracoscopic surgery (VATS). The secondary objective is to record perioperative vital parameters, arterial blood gas values obtained at specific stages of the surgery, and the incidence of postoperative nausea and vomiting (PONV).

NCT Number	NCT07271472
Lead Sponsor	Ataturk University
Conditions	VATS, Video Assisted Thoracoscopic Surgery
Enrollment	60 participants
Start Date	2025-12-01
Primary Completion	2026-05-01 (estimated)
Study Completion	2026-05-02 (estimated)
Updated on ClinicalTrials.gov	2026-05-14