REsorbable SCaffolds With everolimUs-Elution for the Treatment of Infrapopliteal Artery Disease in Patients With Chronic Limb-threatening Ischemia

RESCUE is a Europe-wide study that will follow 400 people with critical limb-threatening ischemia (CLTI). It aims to see how well Esprit BTK™ Everolimus Eluting Resorbable Scaffolds work in real-life medical settings. The study focuses on people who have heavily calcified arteries in the infrapopliteal areas of the leg. These drug-eluting resorbable scaffolds release a medication that helps prevent the inner wall of the blood vessel from thickening after injury or surgery. This can reduce the chance of the artery becoming blocked again (a problem called restenosis), while also giving temporary structural support to the vessel. Over time, the scaffold naturally dissolves in the body, which may lower the long-term risks associated with permanent metal stents.

NCT Number	NCT07270575
Lead Sponsor	Cardiovascular and Interventional Radiological Society of Europe Collaborators: Abbott
Conditions	Chronic Limb Threatening Ischemia, Chronic Limb-Threatening Ischemia
Enrollment	400 participants
Start Date	2026-08
Primary Completion	2032-08 (estimated)
Study Completion	2032-12 (estimated)
Updated on ClinicalTrials.gov	2026-07-07