Longitudinal Natural History Study of Retinal Function in Eyes of Patients With Diabetes

A considerable hurdle to the development of novel, more effective therapies for diabetic retinal disease is the limited number of primary endpoints available for use in regulatory trials. Current endpoints necessitate long trial durations and a greater number of participants to show efficacy. Thus, a better understanding of the structural and functional changes in the retina occurring in people with diabetes is essential for developing primary endpoints and validating surrogate and clinical endpoints.

NCT Number	NCT07270133
Lead Sponsor	Jaeb Center for Health Research Collaborators: National Eye Institute (NEI)
Conditions	Diabetic Retinal Disease
Enrollment	450 participants
Start Date	2026-05-02
Primary Completion	2027-12 (estimated)
Study Completion	2032-12 (estimated)
Updated on ClinicalTrials.gov	2026-04-01