Impact of Dietary Patterns on Prognosis of Ovarian Cancer Patients During PARPi Maintenance

The goal of this retrospective observational study is to evaluate the relationship between different dietary patterns (specifically low-carbohydrate diets) and the prognosis of patients with high-grade serous ovarian cancer (HGSOC) receiving first-line PARP inhibitor (PARPi) maintenance therapy. The main questions it aims to answer are: * Is there an association between dietary patterns and patients' Progression-Free Survival (PFS)? * Is there an association between dietary patterns and Overall Survival (OS)? This is a multicenter, retrospective cohort study. Researchers will review electronic medical records from 14 tertiary hospitals in China to identify women who received first-line PARP inhibitor maintenance for advanced high-grade serous ovarian cancer between 2020 and 2025, and collect information on baseline characteristics, treatments and follow-up outcomes. Researchers will compare patients with a "low-carbohydrate diet pattern" to those with a "regular/high-carbohydrate diet pattern" to see if there are differences in treatment outcomes and survival. Participants will: * Have their clinical, pathological, and treatment data collected from electronic medical records. * Complete a retrospective Food Frequency Questionnaire (FFQ) via phone or clinic visit to recall their dietary habits during the maintenance treatment period. * Optionally provide a blood sample for nutrition and metabolic analysis. (For participants at the main study center only) No experimental drugs or specific diets will be given in this study. All anti-cancer treatments are decided by the treating physicians as part of routine clinical care.

NCT Number	NCT07269574
Lead Sponsor	Tongji Hospital Collaborators: West China Second University Hospital, Peking University People's Hospital, Cancer Hospital Chinese Academy of Medical Science, Shenzhen Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, The Affiliated Hospital of Qingdao University, Qilu Hospital of Shandong University, Shanghai First Maternity and Infant Hospital, First Affiliated Hospital, Sun Yat-Sen University, The First Affiliated Hospital of Soochow University, Henan Provincial People's Hospital, The First Affiliated Hospital of Henan University of Science and Technology, Women's Hospital School Of Medicine Zhejiang University, Sun Yat-Sen University Cancer Center
Conditions	Ovarian Cancer, Fallopian Tube Cancers, Primary Peritoneal Carcinoma, High-grade Serous Ovarian Cancer
Enrollment	600 participants
Start Date	2025-11-27
Primary Completion	2026-11-30 (estimated)
Study Completion	2026-12-31 (estimated)
Updated on ClinicalTrials.gov	2025-12-08