Evaluation of Mechanical Power and Ventilator Parameters to Predict Weaning Success in the Intensive Care Unit

The goal of this prospective observational study is to evaluate whether ventilator-based respiratory parameters can predict weaning success in adult intensive care unit (ICU) patients who are mechanically ventilated. The main questions it aims to answer are: Can the mechanical power (MP) value predict successful extubation? Do other respiratory parameters-airway occlusion pressure (P0.1), negative inspiratory force (NIF), and the rapid shallow breathing index (RSBI)-provide additional prognostic value for weaning outcomes? Participants will: * Be adult ICU patients planned for weaning from mechanical ventilation. * Undergo bedside ventilatory assessment within 2 hours after meeting clinical weaning criteria. * Have the following respiratory parameters measured: MP, P0.1, NIF, and RSBI. * Be monitored for 48 hours after extubation to assess weaning success (defined as no need for reintubation after extubation)

NCT Number	NCT07268989
Lead Sponsor	Anıl Berkay Balıtatlı
Conditions	Weaning Mechanical Ventilation, Mechanical Power, Negative Inspiratory Force, Airway Occlusion Pressure
Enrollment	60 participants
Start Date	2025-07-01
Primary Completion	2026-04-07 (estimated)
Study Completion	2026-04-07 (estimated)
Updated on ClinicalTrials.gov	2026-05-18