1-hour Premedication for Allergy Goal in Emergency: PAGE-1 Study

1-hour Premedication for Allergy Goal in Emergency: PAGE-1 is a prospective, parallel, two-arm, non-inferiority, randomized controlled trial evaluating the safety of a 1-hour (intervention) versus a 4-hour (standard regimen) intravenous (IV) premedication protocol in adult patients in the Emergency Department (ED) with a documented iodinated contrast allergy and requiring computed tomography (CT) imaging for a high-risk indication.

NCT Number	NCT07268248
Lead Sponsor	Paul Peng, MD PhD MSCR
Conditions	Allergic Reaction to Contrast Media, Hypersensitivity Reaction, Computed Tomography, Premedication
Enrollment	540 participants
Start Date	2026-06
Primary Completion	2027-12 (estimated)
Study Completion	2028-06 (estimated)
Updated on ClinicalTrials.gov	2026-02-19