Implementation of the Methylome in the Characterization of Solid Tumors

This study aims to investigate the functional consequences of specific methylation changes and to examine the clinical implications of these alterations. Methylation analysis is a powerful tool for understanding the molecular mechanisms of brain tumors and other solid tumors and can help identify new diagnostic and therapeutic targets. By analyzing DNA methylation patterns in tumor tissue, it is possible to identify genes that are silenced or activated by methylation. This information can be used to develop new biomarkers for early diagnosis and to identify new therapeutic targets that can be used to reverse methylation-mediated gene silencing.

NCT Number	NCT07268066
Lead Sponsor	IRCCS Azienda Ospedaliero-Universitaria di Bologna
Conditions	Solid Tumor Cancer
Enrollment	180 participants
Start Date	2024-05-21
Primary Completion	2026-12-31 (estimated)
Study Completion	2026-12-31 (estimated)
Updated on ClinicalTrials.gov	2025-12-18