Clinical Trial

LLM-Guided Rehabilitation in Degenerative Knee Disease

Study acronym: LLM-RehabKnee
Completed
View on ClinicalTrials.gov →
Summary
This randomized, four-arm clinical trial will investigate the effects of large language model (LLM)-assisted exercise prescriptions integrated with conventional physiotherapy on pain, function and quality of life in adults with degenerative knee disease. Participants will be randomly assigned to conventional physiotherapy alone or to conventional physiotherapy plus an exercise program planned with the assistance of ChatGPT-5, Gemini 2.5 Pro, or DeepSeek V3.1. All participants will receive supervised outpatient physiotherapy two times per week for 8 weeks (16 sessions in total). Outcomes will be assessed at baseline and at the end of the 8-week intervention period by physiotherapists blinded to group allocation.
Protocol Amendment History 4 changes
critical Trial completed 2026-05-29
critical Primary endpoint(s) modified 2026-05-29
critical Trial status changed: Recruiting → Active, Not Recruiting 2026-05-02
notable Primary completion pushed: 2026-03-01 -> 2026-04-20 2026-04-04
Trial Details
NCT Number NCT07267962
Lead Sponsor Kirsehir Ahi Evran Universitesi
Conditions Degenerative Knee Disease
Enrollment 84 participants
Start Date 2025-11-26
Primary Completion 2026-05-15 (estimated)
Study Completion 2026-05-15 (estimated)
Updated on ClinicalTrials.gov 2026-05-28