EARLY Antibiotics aDAptation in Severe Pneumonia(The EARLY ADAPT Study)

The objective of the study is to determine whether rapid multiplex PCR testing of respiratory samples can reduce exposure to broad-spectrum antibiotics in intensive care unit patients with suspected or confirmed ventilator-associated pneumonia, compared to standard diagnostic methods. As secondary objectives, the investigators will study antibiotic management and overall antibiotic consumption, as well as escalation or de-escalation events. The investigators will study the potential clinical impact of using multiplex PCR to see if the length of stay in the intensive care unit is reduced, as well as the duration of mechanical ventilation.

NCT Number	NCT07267624
Lead Sponsor	University Hospital, Geneva Collaborators: BioMérieux, Hospital Fribourg, Switzerland, Hôpital universitaire de Lausanne, Hospital of Neuchâtel, Centre Hospitalier du Centre du Valais, Hospital Lugano
Conditions	VAP - Ventilator Associated Pneumonia, Antibiotic, Antibiotic Stewardship, Antibiotic Prescribing for Acute Respiratory-tract Infections, Intensive Care (ICU)
Enrollment	170 participants
Start Date	2026-06-05
Primary Completion	2027-05-31 (estimated)
Study Completion	2028-06-30 (estimated)
Updated on ClinicalTrials.gov	2026-04-29