Switching From Restasis to TRYPTYR

Switching to acoltremon 0.003% will significantly improve the signs and symptoms of participants who were being treated with Restasis at 28 days post-treatment compared to baseline. Dry eye disease (DED) is a prevalent condition that commonly affects patients of working age in addition to the elderly. DED is a complex condition that results in ocular symptoms such as dryness and burning and signs such as decreased tear production (aqueous deficient DED) or increased tear evaporation (evaporative DED). Unfortunately, there is not a perfect correlation between DED signs and symptoms, which makes diagnosis and timely treatment challenging.

NCT Number	NCT07267299
Lead Sponsor	Southern College of Optometry
Conditions	Dry Eye, Eye Diseases, Chronic Dry Eye
Enrollment	100 participants
Start Date	2025-12-01
Primary Completion	2026-04-01 (estimated)
Study Completion	2026-05-15 (estimated)
Updated on ClinicalTrials.gov	2025-12-05