Clinical Trial

Abuse Liability for Four Heated Tobacco Product (HTP) Consumables and Two HTP Devices

Not Yet Recruiting
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Record status
This record was last updated December 16, 2025 (before its estimated June 2026 completion). Its status may not reflect the trial's current state.
Summary
This is a single-site, open-label, randomized, 8-way crossover study designed to evaluate elements of abuse liability (AL), including subjective effects and physiological measures (pharmacodynamics \[PD\]) and plasma nicotine uptake (pharmacokinetics \[PK\]), during and following ad libitum use of the study investigational products (IPs) by generally healthy adult smokers.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2025-11-24.
Trial Details
NCT Number NCT07267195
Lead Sponsor RAI Services Company
Conditions Smoking, Smoking Behaviors, Tobacco Use, Tobacco Smoking
Enrollment 40 participants
Start Date 2026-01
Primary Completion 2026-06 (estimated)
Study Completion 2026-12 (estimated)
Updated on ClinicalTrials.gov 2025-12-16