Cohort Observing Mechanisms, Progression and Sequelae of Valvular Heart Disease

The objective of this study is to evaluate and predict the progression of moderate cardiac valve stenosis and regurgitation using clinical, biological, echocardiographic, computed tomography (CT), and magnetic resonance imaging (MRI) data. Additionally, the study aims to analyze the potential impact of device-based interventions, pharmacological therapy, and lifestyle modifications on disease progression.

NCT Number	NCT07267117
Lead Sponsor	Second Affiliated Hospital, School of Medicine, Zhejiang University Collaborators: Army Medical Center of PLA, Huaxi Hospital, Fuwai Yunnan Cardiovascular Hospital, People's Hospital of Xinjiang Uygur Autonomous Region, Second Xiangya Hospital of Central South University, Xiangya Hospital of Central South University, The General Hospital of Northern Theater Command, Chinese Academy of Medical Sciences, Fuwai Hospital, Fujian Provincial Hospital, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, The Affiliated Hospital of Qingdao University, Renmin Hospital of Wuhan University, The First Affiliated Hospital of Air Force Medicial University, Navy General Hospital, Beijing
Conditions	Heart Valve Disease, Mitral Valve (MV) Regurgitation, Mitral Valve Disease, Mitral Valve Stenosis, Aortic Valve Disease, Aortic Valve Stenosis, Tricuspid Valve Disease, Tricuspid Valve Regurgitation +6 more
Enrollment	10,000 participants
Start Date	2025-06-01
Primary Completion	2027-12-31 (estimated)
Study Completion	2030-05-31 (estimated)
Updated on ClinicalTrials.gov	2025-12-05