Acute Effects of Transcutaneous Electrical Nerve Stimulation at Acupoints on Nociceptive Transmission

The goal of this clinical trial is to learn if transcutaneous electrical nerve stimulation (TENS) applied to acupoints can modulate pain transmission and cortical processing in healthy adult volunteers. The main questions it aims to answer are: * Does TENS at Zhongzhu (SJ3) and Hegu (LI4) change pain-related evoked potentials (PREPs)? * Does acupoint electrical stimulation alter nociceptive pathways reflected by PREP waveform modulation? Researchers will compare PREPs recorded before and after TENS at the two acupoints to see if TENS produces measurable effects on cortical nociceptive responses. Participants will receive low-frequency TENS applied to Zhongzhu (SJ3) and Hegu (LI4), and undergo PREP assessments before and after the intervention to measure cortical responses to standardized noxious stimuli.

NCT Number	NCT07267052
Lead Sponsor	China Medical University Hospital
Conditions	Pain Management
Enrollment	35 participants
Start Date	2025-09-05
Primary Completion	2026-07-15 (estimated)
Study Completion	2026-07-31 (estimated)
Updated on ClinicalTrials.gov	2026-07-08