Comparison of Oral Antibiotics For Bone Infections of the Leg and Foot

The goal of this clinical trial is to compare different classes of oral antibiotics (beta-lactam and non-beta-lactam antibiotics) for the treatment of bone infections of the leg and foot. The hypothesis is that oral beta-lactam antibiotics work as well as oral non-beta-lactam antibiotics to treat these infections. The first step is to assess whether it is possible to perform the trial by determining whether participants can be recruited and followed successfully. If the trial is proven to be possible, it will be expanded to ensure an answer to whether the two antibiotic classes work as well for the treatment of bone infections of the leg and foot.

NCT Number	NCT07266753
Lead Sponsor	Michael Garron Hospital Collaborators: University Health Network, Toronto, Ottawa Hospital Research Institute
Conditions	Osteomyelitis of Lower Extremities, Osteomyelitis - Foot, Osteomyelitis of the Foot
Enrollment	1,418 participants
Start Date	2026-02-26
Primary Completion	2031-12-31 (estimated)
Study Completion	2033-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-03-27