Single-cell Multiomics and Spatiotemporal Omics Analyze the Mechanism of Liver Degenerative Disease

The purpose of this observational study is to employ single-cell multi-omics and spatial omics technologies to characterize the spatial and immune structures within the livers of patients with fatty liver, hepatic hemangioma, focal nodular hyperplasia, liver fibrosis, cirrhosis, and HBV infection. The primary questions it aims to address are: Investigate the mechanisms of liver degenerative changes during the processes of liver aging, fatty liver, HBV infection, liver fibrosis, and cirrhosis. Characterize the molecular features and cellular networks at different stages of liver degeneration and identify new targets and mechanisms for the cure of the aforementioned diseases. The study will collect peripheral blood and discarded liver tissue from patients with hepatic hemangioma, fatty liver, HBV infection, liver fibrosis, and cirrhosis who are undergoing hepatectomy or liver biopsy.

NCT Number	NCT07265544
Lead Sponsor	Nanfang Hospital, Southern Medical University Collaborators: Beijing Friendship Hospital, Beijing YouAn Hospital, Zhongnan Hospital, Guangzhou General Hospital of Guangzhou Military Command
Conditions	Liver Neoplasm, HBV Infection, Non-alcoholic Fatty Liver Disease NAFLD, Liver Fibrosis
Enrollment	240 participants
Start Date	2023-03-01
Primary Completion	2026-12-31 (estimated)
Study Completion	2027-02-12 (estimated)
Updated on ClinicalTrials.gov	2026-04-14