Exercise During Pregnancy: Effects on the Maternal-Fetal Unit

Metabolic alterations during pregnancy have been associated with adverse maternal-fetal outcomes, including low birth weight and pregnancy complications. Maternal endothelial dysfunction, oxidative stress, insulin resistance, and placental mitochondrial dysfunction are thought to contribute to fetal metabolic disturbances. Lifestyle changes, such as structured exercise during pregnancy, may modulate maternal and placental factors. This randomized controlled trial will evaluate the effects of a multicomponent exercise program during the second and third trimester on maternal functional capacity, vascular health, anthropometry, metabolic biomarkers, placental function, and newborn health outcomes.

NCT Number	NCT07264231
Lead Sponsor	Universidad Pública de Navarra Collaborators: Fundación Instituto de Investigación Sanitaria de Navarra, NavarraBiomed Biomedical Research Center, Complejo Hospitalario de Navarra
Conditions	Pregnancy
Enrollment	64 participants
Start Date	2025-09-01
Primary Completion	2027-12-15 (estimated)
Study Completion	2027-12-20 (estimated)
Updated on ClinicalTrials.gov	2025-12-04