Clinical Trial

Efficacy and Safety of Intrathecal Administration of Thiotepa in Combination With Trastuzumab in Breast Cancer With Leptomeningeal Metastasis

Name: Efficacy and Safety of Intrathecal Administration of Thiotepa in Combination With Trastuzumab in Breast Cancer With Leptomeningeal Metastasis — clinical trial record (NCT07263425)
Creator: DataLookout
License: https://creativecommons.org/licenses/by/4.0/

Recruiting Phase 2

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Summary

Evaluate the efficacy and safety of Intrathecal Administration of Thiotepa in Combination with Trastuzumab via the Ommaya Reservoir in Breast Cancer with Leptomeningeal Metastasis

Trial Details

NCT Number	NCT07263425
Lead Sponsor	The First Affiliated Hospital with Nanjing Medical University Collaborators: The Affiliated Brain Hospital of Nanjing Medical University
Conditions	Leptomeningeal Metastasis of HER2-positive Breast Cancer
Enrollment	26 participants
Start Date	2025-10-27
Primary Completion	2027-10-27 (estimated)
Study Completion	2027-10-27 (estimated)
Updated on ClinicalTrials.gov	2025-12-04