Track this trial free. DataLookout checks ClinicalTrials.gov daily and emails you which fields changed on NCT07263399 (status, enrollment, completion dates, endpoints, sites) when this record is updated. Free accounts track up to 5 trials.

Track this trial

Effect of Hydrogen Gas on Hyperbaric Oxygen Toxicity

StatusNot Yet Recruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗

Record History

  1. Study First Submitted
The goal of this trial is to investigate whether adding a small fraction of hydrogen gas to an oxygen-enriched breathing mixture can reduce pulmonary oxygen toxicity (POT) in healthy and active divers from the Swedish Armed Forces. The main questions it aims to answer are: * Does hydrogen gas reduce oxidative stress and changes in pulmonary function associated with prolonged hyperbaric oxygen exposure? * What are the underlying pathophysiological mechanisms of pulmonary oxygen toxicity? Researchers will compare oxygen-enriched breathing gas with 1-2% hydrogen to oxygen-enriched gas with 1-2% nitrogen (control) to see if hydrogen provides protective effects against POT during hyperbaric exposure. Participants will: * Complete two hyperbaric exposure sessions (hydrogen vs. nitrogen), each lasting 240 minutes at 1.75 ATA * Undergo pulmonary function tests and sampling of blod and urin before and after each session * Serve as their own controls in a double-blind, randomized, crossover study design
Trial Details
NCT Number NCT07263399
Lead Sponsor Blekinge Institute of Technology
Collaborators: Karolinska Institutet, Göteborg University, Lund University, Swedish Armed Forces Diving and Naval Medicine Centre
Conditions
(from sponsor)		 Oxygen Toxicity, Oxidative Stress, Hyperoxia, Hyperbaric Oxygen, Healthy Subjects (HS), Diving Medicine, Hydrogen-oxygen Gas
Related terms Hyperoxia
Enrollment 32 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov