Evaluation of Diaphragmatic Function After Interscalene Block With Liposomal Bupivacaine

The study aims to evaluation the effects of Liposomal Bupivacaine on diaphragmatic function in patients undergoing upper limb surgery who receive Interscalene Brachial Plexus Block. A total of 120 eligible patients will be enrolled and divided into two groups: Group A will receive 20ml of 0.5% Hydrochloride Bupivacaine , while Group B will receive 10ml of 0.5% Hydrochloride Bupivacaine plus 10ml of Liposomal Bupivacaine. Assessments of diaphragmatic function, pulmonary function, and pain intensity will be performed before the block and at different time points after the block, with follow-up for adverse events. The study is scheduled to run from September 2025 to September 2026, with strict adherence to privacy protection and ethical guidelines.

NCT Number	NCT07263295
Lead Sponsor	Zhejiang University
Conditions	Diaphragmatic Function, Metacarpal Fracture, Radius Fracture, Peripheral Nerve Neurolysis, Chronic Ulcer, Upper Extremity Ligament Injury
Enrollment	120 participants
Start Date	2025-12-05
Primary Completion	2026-08-20 (estimated)
Study Completion	2026-08-25 (estimated)
Updated on ClinicalTrials.gov	2026-08-03