Clinical Trial

N-acetylcysteine for Root Canal Treatment of Necrotic Teeth With Apical Periodontitis

Study acronym: NAC
Active, Not Recruiting Phase 2
View on ClinicalTrials.gov →
Record status
This record was last updated December 30, 2025 (before its estimated June 2026 completion). Its status may not reflect the trial's current state.
Summary
A randomized controlled trial comparing the postoperative pain intensity, periapical biomarkers level, and periapical healing in patients with necrotic mature teeth and apical periodontitis treated with N-acetylcysteine (NAC), as an intracanal and adjunctive systemic medication, versus calcium hydroxide (Ca(OH)₂) intracanal medication alone.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2025-11-30.
Status change: Recruiting → Active, Not Recruiting 2025-12-28
Trial Details
NCT Number NCT07262554
Lead Sponsor Alexandria University
Conditions Apical Periodontitis
Enrollment 40 participants
Start Date 2025-11-15
Primary Completion 2026-06 (estimated)
Study Completion 2026-06 (estimated)
Updated on ClinicalTrials.gov 2025-12-30