Assessement of Effectiveness of Seawater Nasal Sprays on Sinonasal Symptoms

The purpose of this post-market clinical investigation is to assess in a real-life setting, the effectiveness, usage, tolerance, safety and satisfaction of 4 isotonic and hypertonic seawater-based CE-marked nasal sprays. The main questions it aims to answer are: * Efficacy, * Safety, * Usage, * Satisfaction, in real-life usage among infants, children, adults and pregnant or breastfeeding women suffering from acute and chronic sinonasal pathologies. The 4 medical devices under investigation will be used in accordance with their intended use, target populations and medical indications.

NCT Number	NCT07262450
Lead Sponsor	Laboratoire de la Mer Collaborators: EVAMED
Conditions	URTI, Bronchiolitis, COVID - 19, Allergic Rhinitis, Chronic Rhinosinusitis (CRS), Post-surgery
Enrollment	1,065 participants
Start Date	2025-08-27
Primary Completion	2026-08 (estimated)
Study Completion	2026-08 (estimated)
Updated on ClinicalTrials.gov	2025-12-03