Clinical Trial

Active Surveillance in Older Women With ER+ Breast Cancer

Study acronym: ACTIVE
Recruiting
View on ClinicalTrials.gov →
Summary
ACTIVE is a prospective, single-arm, phase I/IIa study examining an active surveillance strategy for small, screen-detected, luminal breast cancer. Patients aged 70 or older with clinical stage I ER+/HER2- breast cancer are eligible. The goal of this clinical trial is to learn if an active surveillance strategy (serial imaging rather than therapeutic intervention) is a safe approach to monitor small breast cancers. The main question to answer is the proportion of participants who experience tumor progression by 12 months.
Trial Details
NCT Number NCT07262138
Lead Sponsor University of Pittsburgh
Conditions Early Stage Estrogen Receptor (ER) Positive Breast Cancer
Enrollment 50 participants
Start Date 2025-11-01
Primary Completion 2028-11-01 (estimated)
Study Completion 2030-12-31 (estimated)
Updated on ClinicalTrials.gov 2025-12-03