Hypertension in Children and Young People at Risk of Autosomal Dominant Polycystic Kidney Disease

The goal of this project is to measure the prevalence of Autosomal Dominant Polycystic Kidney Disease (ADPKD) and hypertension in the general population of children and young people at risk of ADPKD, using magnetic resonance imaging (MRI) for rapid diagnosis alongside genetic testing. The main question it aims to answer is: What is the prevalence of hypertension in a population sample of adolescents with ADPKD? Participants will have the following measurements performed: * Height and weight. * Blood pressure. * Non-invasive measurement of arterial stiffness. * Cardiac and renal MRI. * Blood sample. * Genetic testing.

NCT Number	NCT07260071
Lead Sponsor	King's College London Collaborators: Guy's and St Thomas' NHS Foundation Trust
Conditions	Autosomal Dominant Polycystic Kidney Disease (ADPKD
Enrollment	200 participants
Start Date	2025-08-15
Primary Completion	2028-03 (estimated)
Study Completion	2028-03 (estimated)
Updated on ClinicalTrials.gov	2025-12-02