Rapid Management of Resistant Hypertension in the Public Health System (Fast Control)

This is a single-center, open-label, randomized clinical trial conducted at the Instituto Dante Pazzanese de Cardiologia, São Paulo, Brazil. The study evaluates a simplified treatment strategy for patients with apparent resistant hypertension, comparing fixed triple combination therapy (perindopril, indapamide, and amlodipine) with usual care using multiple separate antihypertensive drugs. The primary objective is to compare 24-hour blood pressure control as measured by ABPM at 12 weeks between the two treatment strategies. Enrollment began on July 15, 2023, and this study was registered retrospectively.

NCT Number	NCT07259733
Lead Sponsor	Instituto Dante Pazzanese de Cardiologia Collaborators: Servier
Conditions	Apparent Resistant Hypertension, Hypertension, High Blood Pressure
Enrollment	142 participants
Start Date	2023-07-15
Primary Completion	2026-12-31 (estimated)
Study Completion	2026-12-31 (estimated)
Updated on ClinicalTrials.gov	2025-12-02