Strengthening Hepatitis B Screening, Linkage to Care and Long-Term Monitoring in Phichit Province, Thailand: A Birth Bohort Approach

This study in Phichit province, Thailand, aims to find and support adults born before 1992 who are at high risk for hepatitis B infection. Many people in this group were born before the universal hepatitis B vaccine was available and may not know they are infected. The study will invite nearly 240,000 eligible adults for free hepatitis B screening. Those who test positive will be linked to care at one of 12 district hospitals. Doctors will use simplified 2024 World Health Organization (WHO) guidelines to decide who needs treatment. Eligible individuals will receive a safe, effective daily medicine (tenofovir alafenamide). The study will use community health volunteers and phone reminders to help patients stay in care and take their medication regularly. Over three years, the study will track improvements in liver health and virus levels, aiming to prevent liver cirrhosis and cancer.

NCT Number	NCT07258251
Lead Sponsor	The Task Force for Global Health Collaborators: Phichit Provincial Public Health Office, Ministry of Public Health, Thailand (Host institution), Siriraj Hospital, Ministry of Health, Thailand, Phichit Provincial Hospital, Liver Foundation Thailand, Thai Association for the Study of the Liver
Conditions	Chronic Hepatitis B, Hepatitis B Virus Infection
Enrollment	6,000 participants
Start Date	2026-01-01
Primary Completion	2028-12-31 (estimated)
Study Completion	2028-12-31 (estimated)
Updated on ClinicalTrials.gov	2025-12-02