Antimicrobial and Anti-inflammatory Effects of Simvastatin as an Intracanal Medication

Successful endodontic treatment and a predictable outcome can only be achieved by effective root canal debridement, irrigation, and elimination of microorganisms . The outcome of endodontic treatment performed in controlled clinical environment has demonstrated success rate around 90%. In certain cases, endodontic treatment may fail, one of the most common reasons is inability to eliminate microorganisms from the root canal. When non-surgical root canal therapy fails, the treatment options include orthograde re-treatment, periradicular surgery, or extraction. Simvastatin (SIM) is a drug used primarily to treat hyperlipidemia and protect against cardiovascular diseases. It has been shown to possess pleiotropic effects such as antimicrobial, anti-inflammatory, immunomodulatory, antioxidant, and bone-forming properties . The side chain of this material has a single methyl group. It inhibits hydroxymethyl glutarylcoenzyme reductase that prevents endogenous cholesterol synthesis

NCT Number	NCT07256561
Lead Sponsor	Hadeer Maher Mostafa Mohamed
Conditions	Endodontically Retard Teeth, Periapical Radiolucency
Enrollment	54 participants
Start Date	2025-08-10
Primary Completion	2026-08-01 (estimated)
Study Completion	2026-08-10 (estimated)
Updated on ClinicalTrials.gov	2025-12-01