Anesthesia, Perfusion, and Surgical practicEs in Cardiac Surgery

Perioperative management in cardiac surgery, particularly the use of anesthesia, cardiopulmonary bypass (CPB), and surgical techniques, remains highly variable across institutions. Current international guidelines lack clear recommendations due to insufficient high-quality comparative data. APECx is an adaptive, international, multicenter, prospective, observational study designed to address multiple of these evidence gaps. The adaptive design allows the study to proceed through subsequent phases. Each phase will collect comprehensive global data on specific peri-operative practices and their associated patient outcomes, all within a single, continuously evolving study.

NCT Number	NCT07255924
Lead Sponsor	Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Collaborators: Amsterdam UMC, location AMC, VU University of Amsterdam
Conditions	Cardiac Anaesthesia, Cardiac Surgery, Perfusion, Anesthesia
Enrollment	15,000 participants
Start Date	2026-04-01
Primary Completion	2036-01 (estimated)
Study Completion	2036-01 (estimated)
Updated on ClinicalTrials.gov	2025-12-01