Clinical Trial

PRP vs AD-SVF in Addition to Marrow Stimulation for Knee Chondral Lesion

Active, Not Recruiting Phase 4
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Record status
This record was last updated December 1, 2025 (before its estimated May 2026 completion). Its status may not reflect the trial's current state.
Summary
The goal of this clinical trial is to learn if PRP and adipose-derived stem cells (AD-SVF) enhance healing after knee microfracture for chondral lesions. It will also learn about the safety of the procedure. The main questions it aims to answer are: Do PRP and AD-SVF get better results than PRP alone in patients undergoing arthroscopic microfracture for knee monocompartmental cartilage injuries? What medical problems do participants have when taking drug ABC? Researchers will compare PRP + AD-SVF to PRP alone to see if PRP + AD-SVF work better to treat knee cartilage injuries. Participants will: Undergo knee microfracture and biologics injections at the end of the arthroscopic procedure (PRP+AD-SVF vs PRP). Visit the clinic for checkups and tests at baseline and at 3, 6, 12 months post-treatment, and then annually.
Trial Details
NCT Number NCT07255547
Lead Sponsor Università degli Studi dell'Aquila
Collaborators: Arthrex GmbH
Conditions Knee Chondral Lesion
Enrollment 80 participants
Start Date 2019-05-01
Primary Completion 2026-05 (estimated)
Study Completion 2026-05 (estimated)
Updated on ClinicalTrials.gov 2025-12-01