Study on the Efficacy and Safety of Anesthesia-Induced Sleep Therapy for Refractory Insomnia

The incidence of refractory insomnia is rising annually, with traditional therapies offering limited efficacy. Anesthesia-Induced Sleep (AIS), involving anesthetic infusion like dexmedetomidine, is emerging. Its ability to mimic natural sleep architecture is unclear. Studies confirm AIS can shorten latency and improve sleep efficiency, but neuromodulatory mechanisms and long-term efficacy remain unclear with scarce follow-up data. This study used dexmedetomidine-based AIS under polysomnography to validate its induction of normal sleep architecture, evaluate long-term efficacy and safety, and explore mechanisms, aiming to provide a novel non-pharmacological intervention.

NCT Number	NCT07255027
Lead Sponsor	Beijing Tiantan Hospital Collaborators: Inner Mongolia Autonomous Region Mental Health Center
Conditions	Insomnia
Enrollment	180 participants
Start Date	2025-12-01
Primary Completion	2027-07-01 (estimated)
Study Completion	2027-08-01 (estimated)
Updated on ClinicalTrials.gov	2025-11-28