The Role of Granulation Tissue in Periodontal Regeneration

The goal of this observational study is to distinguish the infectious, healing, and regeneration-related characteristics of two types of gingival granulation tissues, namely infra-osseous and supra-osseous granulation tissues, in people with severe periodontitis (gum disease). Researchers aim to denote if these tissues may play role in healing after periodontal treatment. Researchers will also compare smokers and non-smokers to see if smoking disrupts the healing potential or infectious properties of granulation tissue. Participants will provide gingival fluid (before) and granulation tissue samples (at the time of) periodontal surgery. The main questions this study aims to answer are: 1. Do infra- and supra-osseous granulation tissues have different healing potential and infectious properties? 2. How do these tissues differ in people who smoke compared to people who do not smoke?

NCT Number	NCT07254117
Lead Sponsor	Riga Stradins University Collaborators: University of Turku
Conditions	Periodontal Bone Loss, Periodontitis, Periodontal Disease, Periodontal Diseases, Periodontal Regeneration, Periodontal Granulation Tissue, Vertical Periodontal Bone Defects, Periodontal Healing
Enrollment	46 participants
Start Date	2025-05-29
Primary Completion	2026-09 (estimated)
Study Completion	2026-09 (estimated)
Updated on ClinicalTrials.gov	2025-11-28